The Shawnees called it Spaylaywitheepi. When French traders and trappers arrived during the 18th century, they described it as the Iroquois had: La Belle Rivière — the beautiful river.
Seeing the Ohio today, it’s difficult to believe that, in its original state, the river was a naturally shallow stream, varying in depth from only about 3 to 20 feet. And during annual periods of low water, such as late summer and early fall, a person could literally walk across the Ohio River on the stream’s bottom at many spots. You’d certainly get wet, possibly up to your waist or so, but the feat could be accomplished.